John Mellencamp gives sad update on daughter Teddi’s cancer battle: ‘She’s suffering’

John Mellencamp shared that his youngest daughter, Teddi Mellencamp, isn’t doing well amid her battle with stage 4 brain cancer.

The 74-year-old musician appeared on the “Joe Rogan Experience” podcast Wednesday and brought up Teddi being “really sick.”

“It’s not f–king fun,” John said. “She’s got cancer in the brain, and she’s suffering right now.”

John Mellencamp in a white t-shirt speaking into a microphone.
John Mellencamp gave a sad update on his youngest daughter, Teddi Mellencamp, amid her battle with brain cancer.YouTube/@@joerogan
Teddi Mellencamp in a hospital bed with electrodes on her forehead.
The musician said that the “Real Housewives of Beverly Hills” alum was “suffering right now.”teddimellencamp/Instagram“That kid used to call me up and I’d go, ‘Teddi, you can have a thought without asking me if it’s … you know, figure it out yourself,’” he recalled with a laugh. “You don’t have to ask me everything, you know?”

The “Jack & Diane” singer has five children — daughters Michelle, 55, Teddi, 44, and Justice, 40, as well as younger sons Hud, 31, and Speck, 30 — and admitted it wasn’t always smooth sailing raising them.

“Girls, at about 12 you lose them and then about 21 they come back,” he said. “I kinda lost mine.”

John Mellencamp and Teddi Mellencamp posing for a photo on the red carpet.
John also shared that Teddi frequently asked him for advice growing up, to the point where he told her to “figure it out yourself.”Charles Sykes/Bravo via Getty Images
Teddi Mellencamp with daughters Slate and Dove Arroyave and father John Mellencamp.
The “Jack & Diane” singer noted how his relationship with his five kids improved as they got older.Teddi Mellencamp Arroyave/InstagramTeddi shared her stage 2 melanoma diagnosis in 2022 and has continued to update fans on her health.

After undergoing several procedures to address her cancer-related tumors over the years, she revealed in April 2025 that her cancer had spread to her brain and lungs and progressed to stage 4.

But Teddi gave a major positive update in October 2025, when she said her cancer was “gone” on her “Two T’s in a Pod” podcast.

“I had my immunotherapy yesterday and I did my scans and at this point there is no detectable cancer,” she shared.

Teddi Mellencamp wearing an oxygen mask while lying in a hospital bed.
Teddi revealed her cancer diagnosis in May 2022, and shared in April 2025 that her cancer progressed to stage 4Teddimellencamp/Instagram
Teddi Mellencamp with short blonde hair and blue eyes, wearing a tan hoodie.
The reality star gave a positive update in October 2025, sharing that she had no detectable cancer but clarifying that she’s not in remission.Instagram/Teddi Mellencamp